Phuket Cleanse: Hormesis Therapies

Goes into how Bikram yoga makes the body think it is threatened in various stress ways, and the body responds.
 
Raw food obviously has profound effects. People often claim it is from enzymes.

I wonder if some of the benefit is from plant microRNA.

Juicing also seems like a way to get huge amounts of plant microRNA and polyphenols, all of which have biological effects. You aren't heating, and you're able to eat more polyphenols than if you were eating the whole plant along with its fiber. Juicing is like a way to eat in one day the vegetables you'd normally eat in a week.
 
Seeing that plant microRNA can be important for regulating mammalian functions, I wonder if juicing works in part by supplying huge amounts of plant microRNA.

Effects of dietary phytophenols on the expression of microRNAs involved in mammalian cell homeostasis.
 
I have to wonder if some of the major benefit from coffee enemas is from rectal administration of two potent Nrf2 activators in coffee: cafestol and kahweol.

I know some people think it is from palmitic acid (see S A Wilson coffee for enemas).

Even the underlying mechanism of coffee enemas seems like hormesis to me - taking advantage of a few natural reflexes the body has for toxins (dumping bile, increasing glutathione-s-transferase).

I think it's hormesis. I think most of the things that work for chronic illness (without causing dependence) are hormesis.
 
For as many toxins as we are exposed to, they are pretty small players in the world of the body, where MASSIVE amounts of toxins are being generated by normal metabolism.

I'll say this again. As far as direct effects go (free radicals, DNA damage), the body's own toxins have a far greater effect than almost anything from the outside.

Where toxins become a problem is often when they interfere with the body's own repair mechanisms that it uses to deal with its own metabolic aftermath.

I liked this quotation in Underexposed: What if Radiation is Actually Good for You? :

"It is the repair and removal process (or lack of it) that kills us. Like other toxins, high-level radiation degrades those processes, but low-level actually stimulates them."--Theodore Rockwell

Wow. Huge statement there. "Like other toxins" - suggesting that a major mode of
toxins' negative effects is in degrading our own repair processes.

And then notice that low-level toxin exposures improve and tone this repair and removal process.

So people could be thought of as requiring low level doses of toxins - or doses appropriate to their state of health and their level of exposure to other toxins - to maintain their repair and removal functions in good form.


Mold toxins are particularly bad in that they interfere with protein synthesis and Nrf2, among other things. Many of the negative effects seen from them (like carcinogenesis and organ problems) are from interfering with the systems the body normally uses to protect itself.



 
I'm doing a lot of juicing lately. Not completely a juice fast, but a substantial amount of juice each day and not much solid food.

I notice it's making me detox a lot and that it's stimulating a similar sort of effect to other agents that make me detox a lot, where I have to keep doing it frequently to keep up with the detox from the previous session.

I have to wonder if juicing follows the pattern of other things I'm noticing, where practices that return health to sick people in reliable ways (that don't leave them dependent on medication or supplements) tend to involve hormesis.

Could juicing involve hormesis?

It definitely provides high doses of vitamins and minerals. However, it also provides high doses of polyphenols - higher doses than could be achieved by normal eating.

I just posted in the blog post below an article describing why polyphenols are in some sense toxins.

Is juicing similar to ozone, saunas, radiation hormesis in that we are stressing our bodies somewhat by providing slightly elevated (beyond background/what we were doing before) stressors, and the body responds adaptively?

Perhaps that could explain why juicing does something different and more detoxifying for the body than simply ingesting large amounts of vitamins.

What's different is that the juice contains polyphenols (and plant microRNA) - and I imagine that the benefits of juicing have something to do with consuming large amounts of those.

Juicing also involves a lot of chlorophyll.


Plant microRNA: a small regulatory molecule with big impact.
 
Yep - 
It is funny when people say to avoid all toxins and don't buy hormesis but advocate eating healthy foods like broccoli, red wine, berries, green tea, etc. 

Polyphenols are toxins. The reason they are beneficial is hormesis. 

Many, many substances fit the curve where certain doses are optimal and much higher doses are toxic. 

Polyphenols, Hormesis, and Disease - Part I
Part II




 
I read this article about radiation doses, radiation hormesis, and the effects of several nuclear emergencies.

Nuclear Radiation and Health Effects

What was interesting is that in some of the large-scale emergencies where people were evacuated, most of the deaths and suffering were related to evacuation/displacement and to fear/depression from being told they'd been exposed.

Also there are books that say pretty convincingly the environment isn't so bad, the financial system isn't so bad, the world is getting better, and we have a source of almost unlimited clean energy from nuclear (if we recognize that very low exposures are not harmful and likely beneficial).

I wonder if the idea things are bad appeals to us and we jump on it....

There are many ways fear can be harmful:

Can cause the feared thing to happen (e.g., people dying because given the "evil eye")
Can cause lack of investment in the future
Chronic stress and pessimism


We really don't know what the future holds. It's a mystery. There are so many forces at play that we don't know about - both that we don't know about personally, and some that humans don't know about at all yet (discoveries yet to be made).

It's really a shame, though, when anything, whether tradition or profit, keeps people from being open to changing in the face of new evidence. - whether to realize things might not be that bad, or to take care of things that don't seem
 

You sweat, but toxins likely stay - LA Times

In the past, I would have argued with this and insisted that sweating did release toxins, but now I know other mechanisms by which getting hot to the point of stress can stimulate detoxification (Nrf2, heat shock proteins, etc.).

This is a classic example where the fact that a treatment doesn't work through the proposed mechanism doesn't mean it doesn't work at all. Saunas still work - just through other mechanisms.

Saunas and heat stress have been invaluable to a lot of people with environmental illness and mold illness.



 
The body is capable of healing. The question is whether we can activate those mechanisms. In fact, many of these toxins turn off the mechanisms or turn on other self-protective mechanisms. 

The body needs something like a jump start to start self-healing again.

Many doctors use protocols designed around relieving stress on the body. Taking care of functions it is not doing.

But from what I'm seeing, people are getting better from 1) removing particularly bad toxins and 2) the opposite - from getting more stress, in particular ways, that tells the body "there's a stress" and it starts healing. 

From what I'm seeing, the ways people are getting better often involve hormesis of some sort, whether they know it is hormesis or not.

Vitamin C IVs- at levels that cause hormesis. 
Infrared sauna 
LDN
Many herbs stimulate Nrf2 - hormetins - many of the most favored Lyme herbs
MMS
ozone sauna
ozone
PEMF stimulates Nrf2
homeopathy might work in part this way

I suspect that part of why coffee enemas work is that people are giving themselves more or less IV infusions of some very powerful Nrf2 activators found in coffee (cafestol and kahweol). - rectal absorption is often better than oral. In any event, coffee enemas probably work through hormesis, where the body sees them as a form of toxic stress and responds by dumping bile and the other things that happen.

I keep finding that many things people think are great for Lyme, mold, MCS, MS, and toxicity diseases turn out to have hormetic effects, even when people think they work for other reasons. 

Even eating fruits and vegetables might work in part by exposing us to plant hormetic compounds and plant micro RNA.

- - -

Things that are good for longevity are also often good for healing disease, particularly toxicity diseases. 

Hormesis is also critical for longevity, if you look at anti-aging firewalls and Getting Stronger (two good blogs). 

This seems to be the way the body is built. It might not make sense to our linear western minds, but the body is designed to be kept "toned" by stress, and if it falls out of shape, applying careful stresses can help to get it back to being toned. 

It makes sense - the body is designed to adapt to the environment. If we do its work for it, it will slack off and spend energy elsewhere. If it notices a stress, then it will adapt to that stress.

The trick is convincing the body it is under stress from toxins, hypoxia, pathogens, etc. 

- - -
It's up to you what kind of hormesis you want. You can experiment to see what kind of treatment feels good to you.

Ideally things would be 
a) a one-time cost and
b) not that expensive of a cost

some things in this category: 
water ozonator (Forever Ozone)
radiation hormesis
magnetic pulser

there are also cheap but powerful things that are continuous costs:
Meriva curcumin
EGCG
pterostilbene
germanium 
goldenseal

or large one-time costs
ozone sauna equipment - more for Lyme
infrared sauna - more for mold and chemicals

ones that are not as great:
anything above your price range

I'm all about healing for as little money as possible. 

- - -

Because the body is so adaptive, you have to be very careful about using things that take the place of something the body could be doing for itself. 

Particularly, you have to be careful about taking anything REGULARLY that the body could be doing for itself. 

Some examples: regular use of glutathione, antioxidants, antibiotics, steroids, etc. 

The body can become dependent. 

I personally use some of these occasionally as a one-time toxin flush, like ALA or glutathione, to inundate the system, but i use as low an amount as needed for the effect. Occasional use doesn't send the same message to the body that regular use does, that it's no longer important to do that function for itself. 

- - -
You know you are healing when you get flashbacks to previous times in your life before certain things happened health-wise. 

- - -

There are occasional people who had something bad happen to them and then they discovered some type of hormesis that helped them, and they publicized it or even sell the materials. 

It makes me cry to think that what happened to these people had a more or less direct effect on my life and that I owe my productive life to some of these people. 

People have written to me to say they've gotten their lives back from things I've shared, too.

It's one of the most meaningful things - to experiment when in your own suffering and find tricks that can help others. 

The situation with Lyme and CFS and similar illnesses is still very much at the point where individuals experimenting on themselves are making some of the best headway in getting people better. Just by getting the illnesses, you are in a position to contribute a lot to humanity, since you have your own research lab in your body.

It's not necessarily a choice to get these illnesses, and I doubt anyone would choose to get them, but if it were a choice, it would be a very selfless choice to get these and to be on the ground of battle, trying to figure out how to heal these cheaply and fully. 

Some of the most powerful treatments don't require doctors and aren't even things you take in typical routes (e.g., oral supplementation). 

Instead, many of the most powerful treatments are things that amplify stress messages that would have been there throughout human evolution: from cold (e.g., cold showers), stressed plants, fasting, radiation, elevation, exertion, etc.