I have to wonder if some of the major benefit from coffee enemas is from rectal administration of two potent Nrf2 activators in coffee: cafestol and kahweol.

I know some people think it is from palmitic acid (see S A Wilson coffee for enemas).

Even the underlying mechanism of coffee enemas seems like hormesis to me - taking advantage of a few natural reflexes the body has for toxins (dumping bile, increasing glutathione-s-transferase).

I think it's hormesis. I think most of the things that work for chronic illness (without causing dependence) are hormesis.

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